11β-HSD1 Inhibition Improved Cognitive Decline Associated with High-Fat Diet in Female SAMP8. D. Puigoriol-Illamola1; C. Griñán-Ferré1; J. Companys-Alemany1; R. Leiva-Martínez2; S. Vázquez2; M. Vázquez3; M. Pallàs1. 1 Department of Pharmacology and...
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11β-HSD1 Inhibition Improved Cognitive Decline Associated with High-Fat Diet in Female SAMP8. D. Puigoriol-Illamola1; C. Griñán-Ferré1; J. Companys-Alemany1; R. Leiva-Martínez2; S. Vázquez2; M. Vázquez3; M. Pallàs1. 1 Department of Pharmacology and Therapeutic Chemistry. Pharmacology Section. Institute of Neuroscience. 2 Department of Pharmacology and Therapeutic Chemistry. Therapeutic Chemistry Section. CSIC associated unit. Institute of Biomedicine (IBUB). 3 Department of Pharmacology and Therapeutic Chemistry. Pharmacology Section. Faculty of Pharmacy. University of Barcelona, Av Joan XXIII 27-31. 08028 Barcelona, Spain Aims: Aging and obesity are a global epidemic that significantly affects population health. Mounting evidence suggests elevated glucocorticoid (GC) levels cause obesity, metabolic stress, diabetes and memory impairments. 11β-HSD1 regulates the conversion of GCs from inactive to forms. In our previous work, we determined that inhibition of 11β-HSD1 promotes autophagy
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