Potential Drawbacks Of Pegylated Therapeutic Proteins

PEGylation has delivered sustained success of many therapeutic proteins, together with the number of protein conjugates entering clinical trials. But, it doesn't mean PEGylation is perfect, it also causes some disadvantages of which cannot be neglected,... More

PEGylation has delivered sustained success of many therapeutic proteins, together with the number of protein conjugates entering clinical trials. But, it doesn't mean PEGylation is perfect, it also causes some disadvantages of which cannot be neglected, such as the antibody formation against PEG (anti-PEG), hypersensitivity to PEG and vacuolation. Less