JOURNAL OF THE ROYAL SOCIETY OF MEDICINE Volume 100 April 2007 A lesson learnt: the rise and fall of Lariam and Halfan Ashley M Croft J R Soc Med 2007;100:170–174 INTRODUCTION named, and they were still referred to by their respective Lariam...
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JOURNAL OF THE ROYAL SOCIETY OF MEDICINE Volume 100 April 2007 A lesson learnt: the rise and fall of Lariam and Halfan Ashley M Croft J R Soc Med 2007;100:170–174 INTRODUCTION named, and they were still referred to by their respective Lariam (pharmacological name mefloquine) is an antimalaria Walter Reed experimental numbers: WR 142 490 and WR drug discovered by the US Army shortly after the Vietnam 171 669.1,4 Lariam and Halfan were the two main progeny War, and subsequently marketed worldwide by F. of the WRAIR malaria drug discovery programme, which Hoffmann-La Roche. The first reported trials of mefloquine ran from 1963 until 1976. were in prisoners, and were performed at the Joliet Over a 15-year period, vast resources were voted by the Correctional Center, Illinois, in 1975, and at the Maryland US federal government to fund WRAIR’s antimalaria drug House of Correction in 1976.1,2 research, which at the time was the largest drug discovery Halfan (pharmacological name halofantrine)
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