Sepsis-Phänotypisierung Keine Angst vor der Heterogenität der Sepsis? Neue Ansätze zur Phänotypisierung Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. Seymour CW, Kennedy JN, Wang S, Chang CH,...
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Sepsis-Phänotypisierung Keine Angst vor der Heterogenität der Sepsis? Neue Ansätze zur Phänotypisierung Derivation, validation, and potential treatment implications of novel clinical phenotypes for sepsis. Seymour CW, Kennedy JN, Wang S, Chang CH, Elliott CF, Xu Z, Berry S, Clermont G, Cooper G, et al. JAMA 2019; 321:2003-2017 IMPORTANCE: Sepsis is a heterogeneous syndrome. Identifica- 67 [SD, 17] years; 21 993 [51%] male; mean maximum 24-hour SOFA tion of distinct clinical phenotypes may allow more precise therapy score, 3.6 [SD, 2.0]). Of the 4 derived phenotypes, the α phenotype was and improve care. the most common (n = 6625; 33%) and included patients with the low- OBJECTIVE: To derive sepsis phenotypes from clinical data, deter- est administration of a vasopressor; in the β phenotype (n = 5512; 27%), mine their reproducibility and correlation with host-response biomark- patients were older and had more chronic illness and renal dysfunction; ers and clinical outcomes, and ass
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