Howispituitary-dependenthyperadrenocorticism (PDH)treated?
Themostcommonformofhyperadrenocorticismis
PDH,causedbyasmalltumoronthepituitary
gland.
Thetumorreleasesexcessiveamountsofa
stimulatinghormonecalledACTH,whichtellsthe...
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Howispituitary-dependenthyperadrenocorticism (PDH)treated?
Themostcommonformofhyperadrenocorticismis
PDH,causedbyasmalltumoronthepituitary
gland.
Thetumorreleasesexcessiveamountsofa
stimulatinghormonecalledACTH,whichtellsthe
adrenalglandstoproducelargeamountsof
cortisol.
Theprimarytreatmentoptionfordogswith
thisdiseaseismedicaltherapywithadrugcalled
trilostane.
trilostane.
Thismedicationisgivenonceortwicea
dayfortherestofthedog’slife.
AsmallnumberofdogswithPDHhaveproblems
relatedtothetumorinthepituitary.
Thesedogs
mayhavepersonalitychangesorappearblind.
If
thesesignsarenoted,yourveterinarianmayrecommendanMRIofthebrain,followedbyradiation
therapy.
However,itisuncommonforthese
problemstooccurandmostdogsdoverywellwith
trilostanealone.
trilostanealone.
Howdoesthetrilostanehelp?
Trilostaneslowsdownreleaseofcortisolbythe
adrenalglands.
Thedropincortisollevelsslowly
reversesthechangesassociatedwithHAC,such
asexcessivethirstandhaircoatchanges.
TrilostanedoesnotcuretheunderlyingcauseofPDH
(na
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