Growth Hormone Releasers History
GHRH
There are two known hypothalamic hormones, Growth Hormone Releasing Hormone
(GHRH) and somatostatin, that are key regulators of Growth Hormone (GH) release from
somatotrophs (GH releasing cells) in the pituitary gland;...
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Growth Hormone Releasers History
GHRH
There are two known hypothalamic hormones, Growth Hormone Releasing Hormone
(GHRH) and somatostatin, that are key regulators of Growth Hormone (GH) release from
somatotrophs (GH releasing cells) in the pituitary gland; GHRH stimulates GH secretion,
and somatostatin inhibits GH secretion.
GHS
In addition to GHRH, a synthetic hexapeptide (6-amino-acid peptide), was created in the
late 1970’s by the Bowers’ group and named GHRP-6 (growth hormone releasing peptide
(made up of 6 amino acids) 6).
This peptide was found to illicit a strong GH release
response and so became the first member of a class of growth hormone releasing peptides
called GH secretagogues.
Structurally GHRP-6 is composed of the amino acids L-Histidine, D-Tryptophan, LAlanine, L- Tryptophan, D- Phenylalanine and L- Lysine.
The "L" form called "Levo" of an amino acid is the naturally occurring form and often in
the nomenclature the "L" is dropped.
The "D" form called "Dextro" does
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