Pathophysiology of cardiovascular disease

Kidney International, Vol. 58, Suppl. 76 (2000), pp. S-140–S-147 Pathophysiology of cardiovascular disease in hemodialysis patients FRE´ DE´ RIQUE MEEUS, OLIVIER KOURILSKY, ALAIN P. GUERIN, CATHERINE GAUDRY, SYLVAIN J. MARCHAIS, and GE´ RARD M.... More

Kidney International, Vol. 58, Suppl. 76 (2000), pp. S-140–S-147 Pathophysiology of cardiovascular disease in hemodialysis patients FRE´ DE´ RIQUE MEEUS, OLIVIER KOURILSKY, ALAIN P. GUERIN, CATHERINE GAUDRY, SYLVAIN J. MARCHAIS, and GE´ RARD M. LONDON Center Hospitalier Louise Michel, Evry, and Center Hospitalier F. H. Manhes, Fleury-Me´rogis, France Pathophysiology of cardiovascular disease in hemodialysis pa- to the high mortality of ESRD patients. Macrovascular tients. Cardiovascular disease is the principal cause of morbid- disease develops rapidly in uremic patients and is responity and mortality in dialysis patients. The principal alterations sible for the high incidence of ischemic heart diseaseresponsible are left ventricular hypertrophy and arterial disease [1, 2]. Although the majority of these accidents may becharacterized by an enlargement and hypertrophy of arteries due to atherosclerotic obstructive lesions, in 25 to 30%and the high prevalence of atheromatous p Less