Martel-Frachet et al

Original article 1 Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma Ve`ronique Martel-Fracheta , Julie Areguianb , Madeleine Blancb , Bastien Touqueta , Arnaud Lamarcaa , Xavier Ronota and Ahce`ne... More

Original article 1 Investigation of a new 1,3-diarylpropenone as a potential antimitotic agent targeting bladder carcinoma Ve`ronique Martel-Fracheta , Julie Areguianb , Madeleine Blancb , Bastien Touqueta , Arnaud Lamarcaa , Xavier Ronota and Ahce`ne Boumendjelb 1-(2,4-dimethoxyphenyl)-3-(1-methylindolyl) propenone, namely IPP51, was identified by the screening of a library of 3-indolyl-1-phenylpropenones. The title compound was investigated for its ability to inhibit proliferation and/or to induce apoptosis of human bladder cancer cell lines and to assess its potential use in bladder carcinoma treatment. After treating the cells with the title compound for 24 h, the title compound induced a predominant and reversible G2 + M accumulation at the prometaphase stage of mitosis. However, when used for a longer period, it leads to cell apoptosis. These results suggest that the compound has potential anticancer activities, which could be useful in bladder cancer treatment. Anti-Cancer Less