66 AJN ▼ June 2009 ▼ Vol.
109, No.
6 ajnonline.
com
Watch
FACTORS THAT DECREASE THE
EFFECTIVENESS OF CLOPIDOGREL
• In patients taking both clopidogrel and a proton pump
inhibitor, the drug interaction
that may occur through the
cytochrome P-450 isoenzyme...
More
66 AJN ▼ June 2009 ▼ Vol.
109, No.
6 ajnonline.
com
Watch
FACTORS THAT DECREASE THE
EFFECTIVENESS OF CLOPIDOGREL
• In patients taking both clopidogrel and a proton pump
inhibitor, the drug interaction
that may occur through the
cytochrome P-450 isoenzyme
system can diminish the effectiveness of clopidogrel.
• A genetic variation in the same
isoenzyme system may impair
the metabolism of clopidogrel,
thereby also diminishing the
effectiveness of the drug.
Recent research indicates that
either a drug interaction or
a genetic variation affecting
metabolism can alter the effectiveness of the antiplatelet drug
clopidogrel (Plavix), posing the
risk of possibly life-threatening
cardiovascular complications.
Clopidogrel, which inhibits
platelet aggregation and therefore can prevent blood clots and
cardiovascular events, is prescribed after recent myocardial
infarction or stroke, after acute
coronary syndromes, and as prophylaxis in patients with peripheral arterial disease.
But clopidogre
Less
