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Centennial Review Clinical Advances in the Diagnosis and Therapy of the Interstitial Lung Diseases Talmadge E. King, Jr. Department of Medicine, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California–San... More

Centennial Review Clinical Advances in the Diagnosis and Therapy of the Interstitial Lung Diseases Talmadge E. King, Jr. Department of Medicine, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California–San Francisco, San Francisco, California The last century experienced remarkable advances in the classification, diagnosis, and understanding of the pathogenesis of the interstitial lung diseases. Technological advances, particularly physiologic testing, lung imaging studies, bronchoalveolar lavage, surgical lung biopsy, and histopathologic assessment, improved our understanding of these entities. In particular, the advent of high-resolution computed tomography, the narrowed pathologic definition of usual interstitial pneumonia, and recognition of the prognostic importance of separating usual interstitial pneumonia from other idiopathic interstitial pneumonia patterns have profoundly changed the approach to these processes. Most rece Less