pg-1
Report on Diptheria-Etiolgy,Epid,Pathogenesis,Treatment
Etiology-toxins of corynybacterium diphtheria has two subtypes –toxicogen, non toxicogen.
it is an aerobic, non
motile non spore forming G+ rod.
3 bio types Gravis, mitis, intermedius(toxicogen 3...
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pg-1
Report on Diptheria-Etiolgy,Epid,Pathogenesis,Treatment
Etiology-toxins of corynybacterium diphtheria has two subtypes –toxicogen, non toxicogen.
it is an aerobic, non
motile non spore forming G+ rod.
3 bio types Gravis, mitis, intermedius(toxicogen 3 subtypes).
it is stable in low
temp and is inactivated at >100ºC
Diphtheria toxin-heat liable polypeptide which has A and B subunit.
Incubation period :2-7 days.
Epidemiology- Airborn transmited by infected individuals or carriers( more dangerous b/c asyptomatic).
In air
droplets or direct contact.
On the mucose membrane of respiratory tract or skin abrasions.
Rarely by milk.
Pathology:Toxins are absorbed by mucous membranes causing destruction of epithelium and a superficial
inflammation the necrotic epithelium becomes embedded by fibrin, RBC,WBC and a grayish white pseudo
membrane is formed, commonly in tonsils, pharynx, larynx and nose.
Further absorption of toxins into the blood
causes distant myocardium, liver, kidney ,
Less
