Report on influenza – Report prepared by 1. Dr. Sajid Mahmood, MD (EU), Accident & Emergency Department, NHS Royal infirmary Liverpool United Kingdom. 2. Dr. Adnan Akram, MD (EU), Department of Infectious Diseases. University Hospital Riga Latvia. 3. Dr.

pg-1 Report on influenza – ethiology, epidermiology, pathogenesis, treatment Ethiology - caused by influenza virus – orthomixoviridae family – 3 types A,B,C – single stranded RNA . 8 pieces. Influenza A has 2 main surface antigens – Haemaglutin (H) &... More

pg-1 Report on influenza – ethiology, epidermiology, pathogenesis, treatment Ethiology - caused by influenza virus – orthomixoviridae family – 3 types A,B,C – single stranded RNA . 8 pieces. Influenza A has 2 main surface antigens – Haemaglutin (H) & Neuraminidase (NA). (H)- responcible for cell attachment to host cell and agglutination of RBC further divided into H1,H2,H3. (NA) – Prevent self aggregation and promoting dispersion during budding of new virions from the infected cell. Responsible for receptor destruction. Divided into N1,N2. Epidermiology – transmitted by humans, thru respiratory droplets. IP – 6hrs- 2day Antigenic shift – occurs when major change in antigenic type H2N2—H3N3 occurs due to new RNA segments and are the reason for major pandemics. Antigenic drift – relatively frequent minor changes in antigenic type H / N this is due to small mutations in RNA segments. Pathogenesis – Transmission via droplet inhalation – virus binds to respiratory epithelium – rep Less