Drug– drug interaction (DDI) is an
important issue among the cancer
population.
It is commonly observed in
these patients, especially because they
often receive multiple medications concurrently with complex chemotherapy
regimens.
It was shown previously...
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Drug– drug interaction (DDI) is an
important issue among the cancer
population.
It is commonly observed in
these patients, especially because they
often receive multiple medications concurrently with complex chemotherapy
regimens.
It was shown previously that
patients who are taking multiple medications for the treatment of comorbid illnesses experience an increased incidence
of drug interactions.
1,2
Other factors, such
as age-related renal and/or hepatic insufficiency, can also affect drug metabolism,
elimination, and clearance, causing elderly patients with cancer to become even
more susceptible to DDI effects.
3
Over the past few years, there has
been a paradigm shift in cancer treatment from parenteral to oral drug administration,4
with many of the newly approved anticancer agents being administered orally.
Oral anticancer treatment
offers patients greater convenience and
flexibility for timing and location of drug
administration, reduced use of healthcare
resources, and most i
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