Sistema de Investigación y Desarrollo
The effects of fetal asphyctic preconditioning on inflammatory
cytokines in the placenta
Kim Huei Liem
3
*, Gustavo S.
Escobar
1
*, Jasson Espinoza-Caicedo
1
*,
Danilo Gavilanes
2
* and Peter Chedraui
1
*
1
Instituto...
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Sistema de Investigación y Desarrollo
The effects of fetal asphyctic preconditioning on inflammatory
cytokines in the placenta
Kim Huei Liem
3
*, Gustavo S.
Escobar
1
*, Jasson Espinoza-Caicedo
1
*,
Danilo Gavilanes
2
* and Peter Chedraui
1
*
1
Instituto de Biomedicina, Facultad de Ciencias Médicas, Universidad Católica de Guayaquil, Ecuador
2
University Medical Center, Maastricht, The Netherlands
3
Free University of Amsterdam, The Netherlands
Introduction: Perinatal asphyxia is one of the major causes of neonatal mortality and morbidity, contributing to
neuronal injury which leads to long-term motor and cognitive problems.
Researchers have shown that in the rat
brief episodes of sub-lethal fetal asphyxia (FA) can provoke neuroprotection against a subsequent more severe
perinatal asphyctic insult (PA) at birth.
This is called fetal asphyctic preconditioning (PC).
Recent evidence shows
a down-regulation of inflammatory cytokines in the brain after PC, implicating that PC induces ne
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