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Report on Pathogenesis of diarrohea caused by infectious agents. Report prepared by 1. Dr. Sajid Mahmood, MD (EU), Accident & Emergency Department, NHS Royal infirmary Liverpool United Kingdom. 2. Dr. Adnan Akram, MD (EU), Department of Infectious Disease
3 pages
Published by
Adnan Akram MD
pg - 1
Report on Etiological structure and epidemiology of the acute intestinal infections.
Pathogenesis of
dearrhoeas caused by infectious agents.
- Acute intestinal infections can be due to bacteria, virus, parasitic, toxic or...
[More]
pg - 1
Report on Etiological structure and epidemiology of the acute intestinal infections.
Pathogenesis of
dearrhoeas caused by infectious agents.
- Acute intestinal infections can be due to bacteria, virus, parasitic, toxic or nonspecific/uncertain in etiology.
Factors influencing the growth of bacteria (a) Bacterial features -1) Size of Inoculum - Eg (1) Salmonella 105
(2) V.
cholorea, E-coli 108
(3) Shigella 10 -100 bacteria (4) Giadria, Entamoeba 10-100 cysts
2) Intestinal adherence factors - Eg, V.
cholerae - Toxin co-regulated Pilus (TOP)
ETEC - colonization factor antigen (CFA) EPEC - virulance determinants EHEC - Fimbriae
3) Toxin production – (a) Enterotoxins - produces secretory watery dearrhoea
Eg, I V.
cholerae toxin composed of A&B subunit.
B subunit binds to enterocyte - to ganglioside GMI
receptors& thus a subunit which enters the enterocyteactivates adenyl cyclase increase cAMP increase Cl
secretion & decrease Na+ absorption from intestinal mucosaeFluid accumila
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